The Brazilian was furious after Presnel Kimpembe was adjudged to have handled in the penalty area by VAR after the referee had initially given a corner.
Marcus Rashford stepped up for United to put them 3-1 in front of the night and level at 3-3 on aggregate.
Neymar took to Instagram after the game, and blasted: “This is a disgrace, they put four people that know nothing about football in charge of looking at the replay for VAR.
“There is no penalty. How can it be a handball when it hits his back! Go f*** yourselves!”